Tapentadol and Tramadol are two opioid analgesics approved by the FDA. These two are effective for treating short-term body pain conditions. Physicians recommend Tapentadol and Tramadol for not more than three weeks continuously. Both of them have similar mechanisms of action and the action time is also 30 minutes for both of them. Comparing the analgesics it can be concluded that Tapentadol is two to three times more effective than Tramadol and is safer with fewer side effects, dependency, and addiction.